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Collagen I and the fibroblast: High protein expression requires a new paradigm of post-transcriptional, feedback regulation
BACKGROUND: Scaling protein production seems like a simple perturbation of transcriptional control. However, when embryonic tendon fibroblasts have to produce >50% procollagen and secrete it from the cell 4 times faster than the average protein, this taxes the cellular machinery and requires a fr...
Autor principal: | Schwarz, Richard I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758689/ https://www.ncbi.nlm.nih.gov/pubmed/26900604 http://dx.doi.org/10.1016/j.bbrep.2015.07.007 |
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