GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

Microsatellite expansions are the leading cause of numerous neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with C9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia and with polyglutamine diseases, respectively, localize to neur...

Descripción completa

Detalles Bibliográficos
Autores principales: Burguete, Alondra Schweizer, Almeida, Sandra, Gao, Fen-Biao, Kalb, Robert, Akins, Michael R, Bonini, Nancy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758954/
https://www.ncbi.nlm.nih.gov/pubmed/26650351
http://dx.doi.org/10.7554/eLife.08881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758954/
https://www.ncbi.nlm.nih.gov/pubmed/26650351
http://dx.doi.org/10.7554/eLife.08881

Ejemplares similares