Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Upon stimulation with Th1 cytokines or bacterial lipopolysaccharides, resting macrophages shift their phenotype toward a pro-inflammatory state as part of the innate immune response. LPS-activated macrophages undergo profound metabolic changes to adapt to these new physiological requirements. One ke...

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Detalles Bibliográficos
Autores principales: Meiser, Johannes, Krämer, Lisa, Sapcariu, Sean C., Battello, Nadia, Ghelfi, Jenny, D'Herouel, Aymeric Fouquier, Skupin, Alexander, Hiller, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759172/
https://www.ncbi.nlm.nih.gov/pubmed/26679997
http://dx.doi.org/10.1074/jbc.M115.676817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759172/
https://www.ncbi.nlm.nih.gov/pubmed/26679997
http://dx.doi.org/10.1074/jbc.M115.676817

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