The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option

Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic a...

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Autores principales: Siniscalchi, Antonio, Bonci, Antonello Bonci, Mercuri, Nicola Biagio, Pirritano, Domenico, Squillace, Aida, Sarro, Giovambattista De, Gallelli, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759320/
https://www.ncbi.nlm.nih.gov/pubmed/26630959
http://dx.doi.org/10.2174/1570159X13666150729222643
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author Siniscalchi, Antonio
Bonci, Antonello Bonci
Mercuri, Nicola Biagio
Pirritano, Domenico
Squillace, Aida
Sarro, Giovambattista De
Gallelli, Luca
author_facet Siniscalchi, Antonio
Bonci, Antonello Bonci
Mercuri, Nicola Biagio
Pirritano, Domenico
Squillace, Aida
Sarro, Giovambattista De
Gallelli, Luca
author_sort Siniscalchi, Antonio
collection PubMed
description Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
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spelling pubmed-47593202016-06-01 The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option Siniscalchi, Antonio Bonci, Antonello Bonci Mercuri, Nicola Biagio Pirritano, Domenico Squillace, Aida Sarro, Giovambattista De Gallelli, Luca Curr Neuropharmacol Article Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence. Bentham Science Publishers 2015-12 2015-12 /pmc/articles/PMC4759320/ /pubmed/26630959 http://dx.doi.org/10.2174/1570159X13666150729222643 Text en ©2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Siniscalchi, Antonio
Bonci, Antonello Bonci
Mercuri, Nicola Biagio
Pirritano, Domenico
Squillace, Aida
Sarro, Giovambattista De
Gallelli, Luca
The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option
title The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option
title_full The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option
title_fullStr The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option
title_full_unstemmed The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option
title_short The Role of Topiramate in the Management of Cocaine Addiction: A Possible Therapeutic Option
title_sort role of topiramate in the management of cocaine addiction: a possible therapeutic option
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759320/
https://www.ncbi.nlm.nih.gov/pubmed/26630959
http://dx.doi.org/10.2174/1570159X13666150729222643
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