A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters

With the ever-increasing instances of resistance to frontline TB drugs there is the need to develop novel strategies to fight the worldwide TB epidemic. Boosting the effect of the existing second-line antibiotic ethionamide by inhibiting the mycobacterial transcriptional repressor protein EthR is an...

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Detalles Bibliográficos
Autores principales: Nikiforov, Petar O., Surade, Sachin, Blaszczyk, Michal, Delorme, Vincent, Brodin, Priscille, Baulard, Alain R., Blundell, Tom L., Abell, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759522/
https://www.ncbi.nlm.nih.gov/pubmed/26806381
http://dx.doi.org/10.1039/c5ob02630j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759522/
https://www.ncbi.nlm.nih.gov/pubmed/26806381
http://dx.doi.org/10.1039/c5ob02630j

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