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Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner

Physical forces arising in the extra-cellular environment have a profound impact on cell fate and gene regulation; however the underlying biophysical mechanisms that control this sensitivity remain elusive. It is hypothesized that gene expression may be influenced by the physical deformation of the...

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Detalles Bibliográficos
Autores principales: Haase, Kristina, Macadangdang, Joan K. L., Edrington, Claire H., Cuerrier, Charles M., Hadjiantoniou, Sebastian, Harden, James L., Skerjanc, Ilona S., Pelling, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759536/
https://www.ncbi.nlm.nih.gov/pubmed/26892269
http://dx.doi.org/10.1038/srep21300