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Lentiviral Engineered Fibroblasts Expressing Codon-Optimized COL7A1 Restore Anchoring Fibrils in RDEB

Cells therapies, engineered to secrete replacement proteins, are being developed to ameliorate otherwise debilitating diseases. Recessive dystrophic epidermolysis bullosa (RDEB) is caused by defects of type VII collagen, a protein essential for anchoring fibril formation at the dermal-epidermal junc...

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Detalles Bibliográficos
Autores principales: Georgiadis, Christos, Syed, Farhatullah, Petrova, Anastasia, Abdul-Wahab, Alya, Lwin, Su M., Farzaneh, Farzin, Chan, Lucas, Ghani, Sumera, Fleck, Roland A., Glover, Leanne, McMillan, James R., Chen, Mei, Thrasher, Adrian J., McGrath, John A., Di, Wei-Li, Qasim, Waseem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759620/
https://www.ncbi.nlm.nih.gov/pubmed/26763448
http://dx.doi.org/10.1038/JID.2015.364