Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility

Mice lacking three epidermal barrier proteins—envoplakin, periplakin, and involucrin (EPI-/- mice)—have a defective cornified layer, reduced epidermal γδ T cells, and increased dermal CD4(+) T cells. They are also resistant to developing skin tumors. The tumor-protective mechanism involves signaling...

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Detalles Bibliográficos
Autores principales: Natsuga, Ken, Cipolat, Sara, Watt, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759621/
https://www.ncbi.nlm.nih.gov/pubmed/26763429
http://dx.doi.org/10.1038/JID.2015.383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759621/
https://www.ncbi.nlm.nih.gov/pubmed/26763429
http://dx.doi.org/10.1038/JID.2015.383

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