Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

The small GTPase Rac1 has been implicated in the formation and dissemination of tumours. Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associates with a variety of proteins in the cell thereby regulating various functions, including cell migration. However, activation of Rac1 c...

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Detalles Bibliográficos
Autores principales: Marei, Hadir, Carpy, Alejandro, Woroniuk, Anna, Vennin, Claire, White, Gavin, Timpson, Paul, Macek, Boris, Malliri, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759627/
https://www.ncbi.nlm.nih.gov/pubmed/26887924
http://dx.doi.org/10.1038/ncomms10664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759627/
https://www.ncbi.nlm.nih.gov/pubmed/26887924
http://dx.doi.org/10.1038/ncomms10664

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