Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding

The rates at which domains fold and codons are translated are important factors in determining whether a nascent protein will co-translationally fold and function or misfold and malfunction. Here we develop a chemical kinetic model that calculates a protein domain's co-translational folding cur...

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Detalles Bibliográficos
Autores principales: Nissley, Daniel A., Sharma, Ajeet K., Ahmed, Nabeel, Friedrich, Ulrike A., Kramer, Günter, Bukau, Bernd, O'Brien, Edward P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759629/
https://www.ncbi.nlm.nih.gov/pubmed/26887592
http://dx.doi.org/10.1038/ncomms10341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759629/
https://www.ncbi.nlm.nih.gov/pubmed/26887592
http://dx.doi.org/10.1038/ncomms10341

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