Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we...

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Detalles Bibliográficos
Autores principales: Abid Ali, Ferdos, Renault, Ludovic, Gannon, Julian, Gahlon, Hailey L., Kotecha, Abhay, Zhou, Jin Chuan, Rueda, David, Costa, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759635/
https://www.ncbi.nlm.nih.gov/pubmed/26888060
http://dx.doi.org/10.1038/ncomms10708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759635/
https://www.ncbi.nlm.nih.gov/pubmed/26888060
http://dx.doi.org/10.1038/ncomms10708

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