L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in culture. In the presence of L-Lactate (or Pyruvate)...

Descripción completa

Detalles Bibliográficos
Autores principales: Jourdain, P., Allaman, I., Rothenfusser, K., Fiumelli, H., Marquet, P., Magistretti, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759786/
https://www.ncbi.nlm.nih.gov/pubmed/26893204
http://dx.doi.org/10.1038/srep21250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759786/
https://www.ncbi.nlm.nih.gov/pubmed/26893204
http://dx.doi.org/10.1038/srep21250

Ejemplares similares