Cargando…

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in culture. In the presence of L-Lactate (or Pyruvate)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jourdain, P., Allaman, I., Rothenfusser, K., Fiumelli, H., Marquet, P., Magistretti, P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759786/ https://www.ncbi.nlm.nih.gov/pubmed/26893204 http://dx.doi.org/10.1038/srep21250

Ejemplares similares

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection
por: Jourdain, P., et al.
Publicado: (2018)

L-Lactate Regulates the Expression of Synaptic Plasticity and Neuroprotection Genes in Cortical Neurons: A Transcriptome Analysis
por: Margineanu, Michael B., et al.
Publicado: (2018)

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling
por: Tauffenberger, Arnaud, et al.
Publicado: (2019)

Dopamine protects neurons against glutamate-induced excitotoxicity
por: Vaarmann, A, et al.
Publicado: (2013)

Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
por: Krasil’nikova, Irina, et al.
Publicado: (2019)

Delivering progranulin to neuronal lysosomes protects against excitotoxicity
por: Davis, Skylar E., et al.
Publicado: (2021)

Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
por: Zgodova, Arina, et al.
Publicado: (2022)

Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity
por: Zhou, Xianjin
Publicado: (2023)

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2018)

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture
por: Kim, Sun Hee, et al.
Publicado: (2011)

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity
por: Chen, Wei, et al.
Publicado: (2019)

Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response
por: Ruiz, Asier, et al.
Publicado: (2020)

Intracranial V. cholerae Sialidase Protects against Excitotoxic Neurodegeneration
por: Dhanushkodi, Anandh, et al.
Publicado: (2011)

Peripheral administration of lactate produces antidepressant-like effects
por: Carrard, A, et al.
Publicado: (2018)

Erratum: Peripheral administration of lactate produces antidepressant-like effects
por: Carrard, A, et al.
Publicado: (2016)

Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine
por: Duncan, R. Scott, et al.
Publicado: (2011)

Ciliary Neurotrophic Factor Protects Striatal Neurons against Excitotoxicity by Enhancing Glial Glutamate Uptake
por: Beurrier, Corinne, et al.
Publicado: (2010)

Astaxanthin Protection against Neuronal Excitotoxicity via Glutamate Receptor Inhibition and Improvement of Mitochondrial Function
por: Kandy, Swapna Kannothum, et al.
Publicado: (2022)

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble
por: Jolivet, Renaud, et al.
Publicado: (2015)

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death
por: Divakaruni, Ajit S., et al.
Publicado: (2017)

Protection of taurine and granulocyte colony-stimulating factor against excitotoxicity induced by glutamate in primary cortical neurons
por: Pan, Chunliu, et al.
Publicado: (2010)

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases
por: Prentice, Howard, et al.
Publicado: (2015)

Membrane water for probing neuronal membrane potentials and ionic fluxes at the single cell level
por: Didier, M. E. P., et al.
Publicado: (2018)

Dual‐Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic‐Chemodynamic Therapy
por: Tian, Feng, et al.
Publicado: (2021)

Antidiabetic Drug Metformin Protects Neuronal Cells against Quinolinic Acid-Induced Excitotoxicity by Decreasing Intracellular Calcium
por: Jang, Sujeong, et al.
Publicado: (2018)

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade
por: Canedo-Antelo, Manuel, et al.
Publicado: (2018)

Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress
por: Sutcliffe, Taylor C., et al.
Publicado: (2017)

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory
por: Tadi, Monika, et al.
Publicado: (2015)

l-Lactate: Food for Thoughts, Memory and Behavior
por: Veloz Castillo, María Fernanda, et al.
Publicado: (2021)

Phenoxythiophene sulfonamide compound B355252 protects neuronal cells against glutamate-induced excitotoxicity by attenuating mitochondrial fission and the nuclear translocation of AIF
por: Zhang, Yuxin, et al.
Publicado: (2021)

Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
por: Black, Stefanie A. G., et al.
Publicado: (2014)

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity
por: Hu, Xinxin, et al.
Publicado: (2017)

Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine
por: Boury-Jamot, B, et al.
Publicado: (2016)

A Neurotoxic Ménage-à-trois: Glutamate, Calcium, and Zinc in the Excitotoxic Cascade
por: Granzotto, Alberto, et al.
Publicado: (2020)

Magnolol Reduces Glutamate-Induced Neuronal Excitotoxicity and Protects against Permanent Focal Cerebral Ischemia Up to 4 Hours
por: Lee, Wei-Ting, et al.
Publicado: (2012)

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity
por: Krajewska, Maryla, et al.
Publicado: (2011)

Influences of the circadian clock on neuronal susceptibility to excitotoxicity
por: Karmarkar, Sumedha W., et al.
Publicado: (2013)

Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity
por: Wang, Jiejie, et al.
Publicado: (2020)

Insights on the role of l-lactate as a signaling molecule in skin aging
por: Chirumbolo, Salvatore, et al.
Publicado: (2023)

Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs
por: Wang, Xingtao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3b3dj48vc3d334mnijg2h5kq69