Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT

BACKGROUND: Lung cancer is the leading cause of cancer-related mortality, and new therapeutic options are urgently needed. Non-small cell lung cancer (NSCLC) accounts for approximately 85 % of all lung cancers, with the current standard regimen of care for NSCLC including chemotherapy with pemetrexe...

Descripción completa

Detalles Bibliográficos
Autores principales: Tièche, Colin Charles, Peng, Ren-Wang, Dorn, Patrick, Froment, Laurène, Schmid, Ralph Alexander, Marti, Thomas Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759918/
https://www.ncbi.nlm.nih.gov/pubmed/26895954
http://dx.doi.org/10.1186/s12885-016-2117-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759918/
https://www.ncbi.nlm.nih.gov/pubmed/26895954
http://dx.doi.org/10.1186/s12885-016-2117-4

Ejemplares similares