Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

BACKGROUND: Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. RESULTS: To characterize amyloi...

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Detalles Bibliográficos
Autores principales: Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759965/
https://www.ncbi.nlm.nih.gov/pubmed/26892330
http://dx.doi.org/10.1186/s13041-016-0200-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759965/
https://www.ncbi.nlm.nih.gov/pubmed/26892330
http://dx.doi.org/10.1186/s13041-016-0200-z

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