B7-H4 is a positive regulator of antitumor immunity

B7-H4 (B7x, B7S1, VTCN1, DD-0110) is a member of the B7 superfamily that negatively regulates T cell responses.(1) In addition, B7-H4 expression is increased on tumors and has been shown to be a negative prognostic marker for many cancers.(2) Unexpectedly our recent study demonstrated that B7-H4 inh...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahbar, Ramtin, Ohashi, Pamela S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760282/
https://www.ncbi.nlm.nih.gov/pubmed/26942059
http://dx.doi.org/10.1080/2162402X.2015.1050575
_version_ 1782416856312709120
author Rahbar, Ramtin
Ohashi, Pamela S
author_facet Rahbar, Ramtin
Ohashi, Pamela S
author_sort Rahbar, Ramtin
collection PubMed
description B7-H4 (B7x, B7S1, VTCN1, DD-0110) is a member of the B7 superfamily that negatively regulates T cell responses.(1) In addition, B7-H4 expression is increased on tumors and has been shown to be a negative prognostic marker for many cancers.(2) Unexpectedly our recent study demonstrated that B7-H4 inhibited tumor growth and was required to promote effective antitumor responses.(3)
format Online
Article
Text
id pubmed-4760282
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-47602822016-03-03 B7-H4 is a positive regulator of antitumor immunity Rahbar, Ramtin Ohashi, Pamela S Oncoimmunology Author's View B7-H4 (B7x, B7S1, VTCN1, DD-0110) is a member of the B7 superfamily that negatively regulates T cell responses.(1) In addition, B7-H4 expression is increased on tumors and has been shown to be a negative prognostic marker for many cancers.(2) Unexpectedly our recent study demonstrated that B7-H4 inhibited tumor growth and was required to promote effective antitumor responses.(3) Taylor & Francis 2015-06-01 /pmc/articles/PMC4760282/ /pubmed/26942059 http://dx.doi.org/10.1080/2162402X.2015.1050575 Text en © The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Rahbar, Ramtin
Ohashi, Pamela S
B7-H4 is a positive regulator of antitumor immunity
title B7-H4 is a positive regulator of antitumor immunity
title_full B7-H4 is a positive regulator of antitumor immunity
title_fullStr B7-H4 is a positive regulator of antitumor immunity
title_full_unstemmed B7-H4 is a positive regulator of antitumor immunity
title_short B7-H4 is a positive regulator of antitumor immunity
title_sort b7-h4 is a positive regulator of antitumor immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760282/
https://www.ncbi.nlm.nih.gov/pubmed/26942059
http://dx.doi.org/10.1080/2162402X.2015.1050575
work_keys_str_mv AT rahbarramtin b7h4isapositiveregulatorofantitumorimmunity
AT ohashipamelas b7h4isapositiveregulatorofantitumorimmunity

Ejemplares similares