The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity

We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferre...

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Detalles Bibliográficos
Autor principal: Hargadon, Kristian Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760289/
https://www.ncbi.nlm.nih.gov/pubmed/26942090
http://dx.doi.org/10.1080/2162402X.2015.1069462
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author Hargadon, Kristian Michael
author_facet Hargadon, Kristian Michael
author_sort Hargadon, Kristian Michael
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description We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferred a phenotype upon DC likely to favor immune escape and tumor outgrowth.
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spelling pubmed-47602892016-03-03 The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity Hargadon, Kristian Michael Oncoimmunology Author's View We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferred a phenotype upon DC likely to favor immune escape and tumor outgrowth. Taylor & Francis 2015-08-12 /pmc/articles/PMC4760289/ /pubmed/26942090 http://dx.doi.org/10.1080/2162402X.2015.1069462 Text en © 2016 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Hargadon, Kristian Michael
The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
title The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
title_full The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
title_fullStr The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
title_full_unstemmed The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
title_short The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
title_sort extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760289/
https://www.ncbi.nlm.nih.gov/pubmed/26942090
http://dx.doi.org/10.1080/2162402X.2015.1069462
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