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Tethering in RNA: An RNA-Binding Fragment Discovery Tool

Tethering has been extensively used to study small molecule interactions with proteins through reversible disulfide bond forming reactions to cysteine residues. We describe the adaptation of Tethering to the study of small molecule binding to RNA using a thiol-containing adenosine analog (A(SH)). Am...

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Detalles Bibliográficos
Autores principales: Tran, Kiet, Arkin, Michelle R., Beal, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760646/
https://www.ncbi.nlm.nih.gov/pubmed/25749683
http://dx.doi.org/10.3390/molecules20034148