Cargando…
Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter
Membrane transporters are critical modulators of drug pharmacokinetics, efficacy, and safety. One example is the proton-dependent oligopeptide transporter PepT1, also known as SLC15A1, which is responsible for the uptake of the β-lactam antibiotics and various peptide-based prodrugs. In this study,...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760754/ https://www.ncbi.nlm.nih.gov/pubmed/27028887 http://dx.doi.org/10.1016/j.chembiol.2015.11.015 |