NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators

Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice maintain circadian rhythms in behavior and in tissu...

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Detalles Bibliográficos
Autores principales: Landgraf, Dominic, Wang, Lexie L., Diemer, Tanja, Welsh, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760943/
https://www.ncbi.nlm.nih.gov/pubmed/26895328
http://dx.doi.org/10.1371/journal.pgen.1005882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760943/
https://www.ncbi.nlm.nih.gov/pubmed/26895328
http://dx.doi.org/10.1371/journal.pgen.1005882

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