Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy

Pregnant women are usually excluded from clinical trials. Physiologically based pharmacokinetic (PBPK) modelling may provide a method to predict pharmacokinetics in pregnant women, without the need to perform extensive in vivo clinical trials. Here, we used mechanistic modelling to delineate the pot...

Descripción completa

Detalles Bibliográficos
Autores principales: Colbers, Angela, Greupink, Rick, Litjens, Carlijn, Burger, David, Russel, Frans G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761019/
https://www.ncbi.nlm.nih.gov/pubmed/26369773
http://dx.doi.org/10.1007/s40262-015-0325-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761019/
https://www.ncbi.nlm.nih.gov/pubmed/26369773
http://dx.doi.org/10.1007/s40262-015-0325-8

Ejemplares similares