Application of a Physiologically Based Pharmacokinetic Model to Study Theophylline Metabolism and Its Interactions With Ciprofloxacin and Caffeine

Theophylline is a commonly used bronchodilator. However, due to its narrow therapeutic range, moderate elevation of serum concentration can result in adverse drug reactions (ADRs). ADRs occur because of interhuman pharmacokinetic variability and interactions with coprescribed medicines. We developed...

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Detalles Bibliográficos
Autores principales: Navid, A, Ng, DM, Wong, SE, Lightstone, FC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761233/
https://www.ncbi.nlm.nih.gov/pubmed/26933518
http://dx.doi.org/10.1002/psp4.12061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761233/
https://www.ncbi.nlm.nih.gov/pubmed/26933518
http://dx.doi.org/10.1002/psp4.12061

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