Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

REV-ERBα and REV-ERBβ nuclear receptors regulate several physiological processes, including circadian rhythm and metabolism. A previous study reported the REV-ERBα gene to be co-overexpressed with ERBB2 in breast cancer cell lines. Surprisingly, we found that several tumor types, including a number...

Descripción completa

Detalles Bibliográficos
Autores principales: De Mei, C, Ercolani, L, Parodi, C, Veronesi, M, Vecchio, C Lo, Bottegoni, G, Torrente, E, Scarpelli, R, Marotta, R, Ruffili, R, Mattioli, M, Reggiani, A, Wade, M, Grimaldi, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761647/
https://www.ncbi.nlm.nih.gov/pubmed/25023698
http://dx.doi.org/10.1038/onc.2014.203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761647/
https://www.ncbi.nlm.nih.gov/pubmed/25023698
http://dx.doi.org/10.1038/onc.2014.203

Ejemplares similares