Entry of PIP3-containing polyplexes into MDCK epithelial cells by local apical-basal polarity reversal

The polarized architecture of epithelium presents a barrier to therapeutic drug/gene carriers, which is mainly due to a limited (apical) internalization of the carrier systems. The bacterium Pseudomonas aeruginosa invades epithelial cells by inducing production of apical phosphatidylinositol-3, 4, 5...

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Detalles Bibliográficos
Autores principales: Wang, Cuifeng, de Jong, Edwin, Sjollema, Klaas A., Zuhorn, Inge S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761886/
https://www.ncbi.nlm.nih.gov/pubmed/26899207
http://dx.doi.org/10.1038/srep21436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761886/
https://www.ncbi.nlm.nih.gov/pubmed/26899207
http://dx.doi.org/10.1038/srep21436

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