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Entry of PIP3-containing polyplexes into MDCK epithelial cells by local apical-basal polarity reversal
The polarized architecture of epithelium presents a barrier to therapeutic drug/gene carriers, which is mainly due to a limited (apical) internalization of the carrier systems. The bacterium Pseudomonas aeruginosa invades epithelial cells by inducing production of apical phosphatidylinositol-3, 4, 5...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761886/ https://www.ncbi.nlm.nih.gov/pubmed/26899207 http://dx.doi.org/10.1038/srep21436 |