Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

Although hepatocyte-like cells derived from human pluripotent stem cells (hPSC-HLCs) are considered a promising model for predicting hepatotoxicity, their application has been restricted because of the low activity of drug metabolizing enzymes (DMEs). Here we found that the low expression of xenobio...

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Detalles Bibliográficos
Autores principales: Kim, Hye-Min, Kim, Ji-Woo, Choi, Youngjun, Chun, Hang-Suk, Im, Ilkyun, Han, Yong-Mahn, Song, Chang-Woo, Yoon, Seokjoo, Park, Han-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761945/
https://www.ncbi.nlm.nih.gov/pubmed/26899675
http://dx.doi.org/10.1038/srep21684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761945/
https://www.ncbi.nlm.nih.gov/pubmed/26899675
http://dx.doi.org/10.1038/srep21684

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