Cargando…

Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

Although hepatocyte-like cells derived from human pluripotent stem cells (hPSC-HLCs) are considered a promising model for predicting hepatotoxicity, their application has been restricted because of the low activity of drug metabolizing enzymes (DMEs). Here we found that the low expression of xenobio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hye-Min, Kim, Ji-Woo, Choi, Youngjun, Chun, Hang-Suk, Im, Ilkyun, Han, Yong-Mahn, Song, Chang-Woo, Yoon, Seokjoo, Park, Han-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761945/ https://www.ncbi.nlm.nih.gov/pubmed/26899675 http://dx.doi.org/10.1038/srep21684

Ejemplares similares

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes
por: Park, Han-Jin, et al.
Publicado: (2015)

Generation of PDGFRα(+) Cardioblasts from Pluripotent Stem Cells
por: Hong, Seon Pyo, et al.
Publicado: (2017)

Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells
por: Do, Hyo-Sang, et al.
Publicado: (2020)

Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions
por: Wang, Juan, et al.
Publicado: (2015)

Differential Effects of Omeprazole and Lansoprazole Enantiomers on Aryl Hydrocarbon Receptor in Human Hepatocytes and Cell Lines
por: Novotna, Aneta, et al.
Publicado: (2014)

Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells
por: Leung, Amy, et al.
Publicado: (2018)

Aryl Hydrocarbon Receptor Repressor Is Hypomethylated in Psoriasis and Promotes Psoriasis-like Inflammation in HaCaT Cells
por: Um, Ji-Young, et al.
Publicado: (2021)

Aryl Hydrocarbon Receptor and Stem Cells
por: Gasiewicz, Thomas A., et al.
Publicado: (2017)

Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice
por: Schuran, Fenja A., et al.
Publicado: (2020)

Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications
por: Rust, Ruslan, et al.
Publicado: (2022)

Aryl hydrocarbon receptor antagonism before reperfusion attenuates cerebral ischaemia/reperfusion injury in rats
por: Kwon, Jae-Im, et al.
Publicado: (2020)

Chemically defined and xeno-free culture condition for human extended pluripotent stem cells
por: Liu, Bei, et al.
Publicado: (2021)

Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
por: Kim, Han-Bi, et al.
Publicado: (2022)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
por: Hubbard, Troy D., et al.
Publicado: (2015)

Role of Aryl Hydrocarbon Receptor Activation and Autophagy in Psoriasis-Related Inflammation
por: Kim, Hye Ran, et al.
Publicado: (2020)

Long-term xeno-free culture of human pluripotent stem cells on hydrogels with optimal elasticity
por: Higuchi, Akon, et al.
Publicado: (2015)

A chemically-defined plastic scaffold for the xeno-free production of human pluripotent stem cells
por: Shimizu, Eiko, et al.
Publicado: (2022)

Is aryl hydrocarbon receptor antagonism after ischemia effective in alleviating acute hepatic ischemia-reperfusion injury in rats?
por: Kwon, Jae-Im, et al.
Publicado: (2023)

Toward Xeno-Free Differentiation of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells
por: Saari, Jaakko, et al.
Publicado: (2022)

Regulation of Innate Lymphoid Cells by Aryl Hydrocarbon Receptor
por: Li, Shiyang, et al.
Publicado: (2018)

Xeno-free culture of human pluripotent stem cells on oligopeptide-grafted hydrogels with various molecular designs
por: Chen, Yen-Ming, et al.
Publicado: (2017)

Development and evaluation of a novel xeno-free culture medium for human-induced pluripotent stem cells
por: Hua, Ying, et al.
Publicado: (2022)

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions
por: Bao, Xiaoping, et al.
Publicado: (2016)

Indole Treatment Alleviates Intestinal Tissue Damage Induced by Chicken Coccidiosis Through Activation of the Aryl Hydrocarbon Receptor
por: Kim, Woo H., et al.
Publicado: (2019)

Toward the defined and xeno-free differentiation of functional human pluripotent stem cell–derived retinal pigment epithelial cells
por: Vaajasaari, Hanna, et al.
Publicado: (2011)

Enhanced Expansion of Human Pluripotent Stem Cells and Somatic Cell Reprogramming Using Defined and Xeno-Free Culture Conditions
por: Timilsina, Suraj, et al.
Publicado: (2023)

Activation of Aryl Hydrocarbon Receptor by ITE Improves Cardiac Function in Mice After Myocardial Infarction
por: Seong, Eunhwa, et al.
Publicado: (2021)

Involvement of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Repressor in Helicobacter Pylori-related Gastric Pathogenesis
por: Zhu, Renfei, et al.
Publicado: (2018)

The aryl hydrocarbon receptor controls cell-fate decisions in B cells
por: Vaidyanathan, Bharat, et al.
Publicado: (2017)

Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor
por: Helm, Eric Y., et al.
Publicado: (2023)

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation
por: Villa, Matteo, et al.
Publicado: (2016)

An effective serum- and xeno-free chemically defined freezing procedure for human embryonic and induced pluripotent stem cells
por: Holm, Frida, et al.
Publicado: (2010)

A Synthetic, Xeno-Free Peptide Surface for Expansion and Directed Differentiation of Human Induced Pluripotent Stem Cells
por: Jin, Sha, et al.
Publicado: (2012)

GMP-compatible and xeno-free cultivation of mesenchymal progenitors derived from human-induced pluripotent stem cells
por: McGrath, Madison, et al.
Publicado: (2019)

High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids
por: Nayler, Samuel, et al.
Publicado: (2021)

The aryl hydrocarbon receptor in tumor immunity
por: Platten, Michael, et al.
Publicado: (2012)

Antioxidant Functions of the Aryl Hydrocarbon Receptor
por: Dietrich, Cornelia
Publicado: (2016)

The Aryl Hydrocarbon Receptor and Tumor Immunity
por: Xue, Ping, et al.
Publicado: (2018)

The Aryl Hydrocarbon Receptor and the Nervous System
por: Juricek, Ludmila, et al.
Publicado: (2018)

The aryl hydrocarbon receptor in liver inflammation
por: Carambia, Antonella, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gu21ecc75bi42fipodouuldvqb