Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4

We report a detailed computational and experimental study of the interaction of single-walled carbon nanotubes (SWCNTs) with the drug-metabolizing cytochrome P450 enzyme, CYP3A4. Dose-dependent inhibition of CYP3A4-mediated conversion of the model compound, testosterone, to its major metabolite, 6β-...

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Detalles Bibliográficos
Autores principales: El-Sayed, Ramy, Bhattacharya, Kunal, Gu, Zonglin, Yang, Zaixing, Weber, Jeffrey K., Li, Hu, Leifer, Klaus, Zhao, Yichen, Toprak, Muhammet S., Zhou, Ruhong, Fadeel, Bengt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761960/
https://www.ncbi.nlm.nih.gov/pubmed/26899743
http://dx.doi.org/10.1038/srep21316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761960/
https://www.ncbi.nlm.nih.gov/pubmed/26899743
http://dx.doi.org/10.1038/srep21316

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