Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction

Acetaminophen (APAP) is extensively used as an analgesic and antipyretic drug. APAP is partly metabolized to N-acetyl-p-benzoquinone imine, a reactive metabolite, by cytochrome P450 (CYP) 1A2, 2E1 and 3A4. Some reports have indicated that CYP3A protein production and its metabolic activity are induc...

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Detalles Bibliográficos
Autores principales: Santoh, Masataka, Sanoh, Seigo, Takagi, Masashi, Ejiri, Yoko, Kotake, Yaichiro, Ohta, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761967/
https://www.ncbi.nlm.nih.gov/pubmed/26900149
http://dx.doi.org/10.1038/srep21373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761967/
https://www.ncbi.nlm.nih.gov/pubmed/26900149
http://dx.doi.org/10.1038/srep21373

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