Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization

Conformational changes of Aβ peptide result in its transformation from native monomeric state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks of Alzheimer’s disease (AD). Interactions of zinc ions with Aβ are mediated by the N-terminal Aβ(1–16) domain and appear to...

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Detalles Bibliográficos
Autores principales: Istrate, Andrey N., Kozin, Sergey A., Zhokhov, Sergey S., Mantsyzov, Alexey B., Kechko, Olga I., Pastore, Annalisa, Makarov, Alexander A., Polshakov, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761979/
https://www.ncbi.nlm.nih.gov/pubmed/26898943
http://dx.doi.org/10.1038/srep21734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761979/
https://www.ncbi.nlm.nih.gov/pubmed/26898943
http://dx.doi.org/10.1038/srep21734

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