deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample. RESULTS:...

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Detalles Bibliográficos
Autores principales: Rosenthal, Rachel, McGranahan, Nicholas, Herrero, Javier, Taylor, Barry S., Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762164/
https://www.ncbi.nlm.nih.gov/pubmed/26899170
http://dx.doi.org/10.1186/s13059-016-0893-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762164/
https://www.ncbi.nlm.nih.gov/pubmed/26899170
http://dx.doi.org/10.1186/s13059-016-0893-4

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