Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells

Podophyllotoxin (PT) and its clinically used analogues are known to be powerful antitumour agents. These compounds contain a trans fused strained γ-lactone system, a feature that correlates to the process of epimerisation, whereby the trans γ-lactone system of ring D opens and converts to the more t...

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Detalles Bibliográficos
Autores principales: Kandil, Sahar, Wymant, Jennifer M., Kariuki, Benson M., Jones, Arwyn T., McGuigan, Christopher, Westwell, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762250/
https://www.ncbi.nlm.nih.gov/pubmed/26854430
http://dx.doi.org/10.1016/j.ejmech.2015.12.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762250/
https://www.ncbi.nlm.nih.gov/pubmed/26854430
http://dx.doi.org/10.1016/j.ejmech.2015.12.037

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