Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways

INTRODUCTION: mTOR and MDM2 signaling pathways are frequently deregulated in cancer development, and inhibition of mTOR or MDM2 independently enhances carcinoma-cell apoptosis. However, responses to mTOR and MDM2 antagonists in renal cell carcinoma (RCC) remain unknown. MATERIALS AND METHODS: A498 c...

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Detalles Bibliográficos
Autores principales: Liu, Qing-jun, Shen, Hong-liang, Lin, Jun, Xu, Xiu-hong, Ji, Zheng-guo, Han, Xiao, Shang, Dong-hao, Yang, Pei-qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762585/
https://www.ncbi.nlm.nih.gov/pubmed/26937175
http://dx.doi.org/10.2147/DDDT.S88779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762585/
https://www.ncbi.nlm.nih.gov/pubmed/26937175
http://dx.doi.org/10.2147/DDDT.S88779

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