Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12

Human S100A12 is a host-defense protein expressed and released by neutrophils that contributes to innate immunity. Apo S100A12 is a 21 kDa antiparallel homodimer that harbors two Ca(ii)-binding EF-hand domains per subunit and exhibits two His(3)Asp motifs for chelating transition metal ions at the h...

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Detalles Bibliográficos
Autores principales: Cunden, Lisa S., Gaillard, Aleth, Nolan, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762610/
https://www.ncbi.nlm.nih.gov/pubmed/26913170
http://dx.doi.org/10.1039/c5sc03655k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762610/
https://www.ncbi.nlm.nih.gov/pubmed/26913170
http://dx.doi.org/10.1039/c5sc03655k

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