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Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12
Human S100A12 is a host-defense protein expressed and released by neutrophils that contributes to innate immunity. Apo S100A12 is a 21 kDa antiparallel homodimer that harbors two Ca(ii)-binding EF-hand domains per subunit and exhibits two His(3)Asp motifs for chelating transition metal ions at the h...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762610/ https://www.ncbi.nlm.nih.gov/pubmed/26913170 http://dx.doi.org/10.1039/c5sc03655k |