DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions

Th17 lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation is controlled by RORγt, a ligand-regulated nuclear receptor. We identified the DEAD-box RNA helicase DDX5 as a RORγt partner that coordinates transcription...

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Detalles Bibliográficos
Autores principales: Huang, Wendy, Thomas, Benjamin, Flynn, Ryan A., Gavzy, Samuel J., Wu, Lin, Kim, Sangwon V., Hall, Jason A., Miraldi, Emily R., Ng, Charles P., Rigo, Frank, Meadows, Sarah, Montoya, Nina R., Herrera, Natalia G., Domingos, Ana I., Rastinejad, Fraydoon, Myers, Richard M., Fuller-Pace, Frances V., Bonneau, Richard, Chang, Howard Y., Acuto, Oreste, Littman, Dan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762670/
https://www.ncbi.nlm.nih.gov/pubmed/26675721
http://dx.doi.org/10.1038/nature16193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762670/
https://www.ncbi.nlm.nih.gov/pubmed/26675721
http://dx.doi.org/10.1038/nature16193

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