Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL). We studied 522 Danish children with ALL, 93% of all those elig...

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Detalles Bibliográficos
Autores principales: Gregers, J, Gréen, H, Christensen, I J, Dalhoff, K, Schroeder, H, Carlsen, N, Rosthoej, S, Lausen, B, Schmiegelow, K, Peterson, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762905/
https://www.ncbi.nlm.nih.gov/pubmed/25582575
http://dx.doi.org/10.1038/tpj.2014.81

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762905/
https://www.ncbi.nlm.nih.gov/pubmed/25582575
http://dx.doi.org/10.1038/tpj.2014.81

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