Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models

ABSTRACT: Huntington’s disease (HD) is a genetic disease caused by a CAG trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin (HTT) protein, ultimately leading to neuronal loss and consequent cognitive decline and death. As no treatments for HD currently exist, several che...

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Detalles Bibliográficos
Autores principales: Smalley, Joshua L., Breda, Carlo, Mason, Robert P., Kooner, Gurdeep, Luthi-Carter, Ruth, Gant, Timothy W., Giorgini, Flaviano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762922/
https://www.ncbi.nlm.nih.gov/pubmed/26428929
http://dx.doi.org/10.1007/s00109-015-1344-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762922/
https://www.ncbi.nlm.nih.gov/pubmed/26428929
http://dx.doi.org/10.1007/s00109-015-1344-5

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