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Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models
ABSTRACT: Huntington’s disease (HD) is a genetic disease caused by a CAG trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin (HTT) protein, ultimately leading to neuronal loss and consequent cognitive decline and death. As no treatments for HD currently exist, several che...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762922/ https://www.ncbi.nlm.nih.gov/pubmed/26428929 http://dx.doi.org/10.1007/s00109-015-1344-5 |