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Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters

Since Otto Warburg reported the ‘addiction’ of cancer cells to fermentative glycolysis, a metabolic pathway that provides energy and building blocks, thousands of studies have shed new light on the molecular mechanisms contributing to altered cancer metabolism. Hypoxia, through hypoxia-inducible fac...

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Detalles Bibliográficos
Autores principales: Marchiq, Ibtissam, Pouysségur, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762928/
https://www.ncbi.nlm.nih.gov/pubmed/26099350
http://dx.doi.org/10.1007/s00109-015-1307-x