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Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters
Since Otto Warburg reported the ‘addiction’ of cancer cells to fermentative glycolysis, a metabolic pathway that provides energy and building blocks, thousands of studies have shed new light on the molecular mechanisms contributing to altered cancer metabolism. Hypoxia, through hypoxia-inducible fac...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762928/ https://www.ncbi.nlm.nih.gov/pubmed/26099350 http://dx.doi.org/10.1007/s00109-015-1307-x |