Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and t...

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Detalles Bibliográficos
Autores principales: Hermann, Andreas, Kim, Jeong Beom, Srimasorn, Sumitra, Zaehres, Holm, Reinhardt, Peter, Schöler, Hans R., Storch, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763001/
https://www.ncbi.nlm.nih.gov/pubmed/26977154
http://dx.doi.org/10.1155/2016/4736159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763001/
https://www.ncbi.nlm.nih.gov/pubmed/26977154
http://dx.doi.org/10.1155/2016/4736159

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