High-throughput imaging method for direct assessment of GM1 ganglioside levels in mammalian cells

GM1-gangliosidosis is an inherited autosomal recessive disorder caused by mutations in the gene GLB1, which encodes acid β-galactosidase (β-gal). The lack of activity in this lysosomal enzyme leads to accumulation of GM1 gangliosides (GM1) in cells. We have developed a high-content-imaging method to...

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Detalles Bibliográficos
Autores principales: Acosta, Walter, Martin, Reid, Radin, David N., Cramer, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763105/
https://www.ncbi.nlm.nih.gov/pubmed/26958633
http://dx.doi.org/10.1016/j.dib.2016.01.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763105/
https://www.ncbi.nlm.nih.gov/pubmed/26958633
http://dx.doi.org/10.1016/j.dib.2016.01.027

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