Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

Mismatch of human leukocyte antigens (HLA) adversely impacts the outcome of patients after allogeneic hematopoietic stem-cell transplantation (alloHSCT). This translates into the clinical requirement to timely identify suitable HLA-matched donors which in turn curtails the chances of recipients, esp...

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Detalles Bibliográficos
Autores principales: Torikai, Hiroki, Mi, Tiejuan, Gragert, Loren, Maiers, Martin, Najjar, Amer, Ang, Sonny, Maiti, Sourindra, Dai, Jianliang, Switzer, Kirsten C., Huls, Helen, Dulay, Gladys P., Reik, Andreas, Rebar, Edward J., Holmes, Michael C., Gregory, Philip D., Champlin, Richard E., Shpall, Elizabeth J., Cooper, Laurence J. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763194/
https://www.ncbi.nlm.nih.gov/pubmed/26902653
http://dx.doi.org/10.1038/srep21757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763194/
https://www.ncbi.nlm.nih.gov/pubmed/26902653
http://dx.doi.org/10.1038/srep21757

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