Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine kinase is frequently inactivated by the oncogenic signalling kinases PI3K/Akt and MAPK/ERK in diverse malignancies. The present study was designed to investigate GSK-3β signalling circuits in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced h...

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Detalles Bibliográficos
Autores principales: Sophia, Josephraj, Kiran Kishore T., Kranthi, Kowshik, Jaganathan, Mishra, Rajakishore, Nagini, Siddavaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763291/
https://www.ncbi.nlm.nih.gov/pubmed/26902162
http://dx.doi.org/10.1038/srep22192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763291/
https://www.ncbi.nlm.nih.gov/pubmed/26902162
http://dx.doi.org/10.1038/srep22192

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