Cargando…

Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine kinase is frequently inactivated by the oncogenic signalling kinases PI3K/Akt and MAPK/ERK in diverse malignancies. The present study was designed to investigate GSK-3β signalling circuits in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sophia, Josephraj, Kiran Kishore T., Kranthi, Kowshik, Jaganathan, Mishra, Rajakishore, Nagini, Siddavaram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763291/ https://www.ncbi.nlm.nih.gov/pubmed/26902162 http://dx.doi.org/10.1038/srep22192

Ejemplares similares

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
por: Sophia, Josephraj, et al.
Publicado: (2018)

Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model
por: Kowshik, Jaganathan, et al.
Publicado: (2017)

Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression
por: Mishra, Rajakishore, et al.
Publicado: (2015)

In-vitro Morphological Assessment of Apoptosis Induced by Nimbolide; A Limonoid from Azadirachta Indica (Neem Tree)
por: Kashif, Muhammad, et al.
Publicado: (2019)

Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells
por: Patra, Arjun, et al.
Publicado: (2019)

Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer
por: Kowshik, J., et al.
Publicado: (2014)

Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases
por: Sala, Valentina, et al.
Publicado: (2021)

Glycogen synthase kinase 3 beta: can it be a target for oral cancer
por: Mishra, Rajakishore
Publicado: (2010)

BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma
por: Speranza, Maria-Carmela, et al.
Publicado: (2016)

Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin Signaling Pathway in Caenorhabditis elegans
por: Karmacharya, Rakesh, et al.
Publicado: (2009)

Nimbolide B and Nimbic Acid B, Phytotoxic Substances in Neem Leaves with Allelopathic Activity
por: Kato-Noguchi, Hisashi, et al.
Publicado: (2014)

Fas-Induced Apoptosis of Human Neutrophils is Promoted by Phosphatidyl Inositol 3-Kinase but Suppressed by P38-MAPK Activity
por: Alvarado-Kristensson, Maria, et al.
Publicado: (2001)

Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain
por: Arroyo, Daniela S., et al.
Publicado: (2018)

Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)
por: Behari, Jatin, et al.
Publicado: (2021)

Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis
por: Wu, Zuoxing, et al.
Publicado: (2023)

Microwave-Assisted Improved Extraction and Purification of Anticancer Nimbolide from Azadirachta indica (Neem) Leaves
por: Suttiarporn, Panawan, et al.
Publicado: (2020)

Clinical significance of Phosphatidyl Inositol Synthase overexpression in oral cancer
por: Kaur, Jatinder, et al.
Publicado: (2010)

Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies
por: Bielas, Stephanie L., et al.
Publicado: (2009)

Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis
por: Dembowy, J, et al.
Publicado: (2015)

The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia
por: Allegretti, Matteo, et al.
Publicado: (2015)

Gene Expression Signature of DMBA-Induced Hamster Buccal Pouch Carcinomas: Modulation by Chlorophyllin and Ellagic Acid
por: Vidya Priyadarsini, Ramamurthi, et al.
Publicado: (2012)

Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
por: Jeong, Ju-yeon, et al.
Publicado: (2013)

Erratum: The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia
por: Allegretti, Matteo, et al.
Publicado: (2016)

Comparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model
por: Letchoumy, Paramasivame Vidjaya, et al.
Publicado: (2007)

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells
por: Arjumand, Wani, et al.
Publicado: (2016)

Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
por: Choi, Eun Ok, et al.
Publicado: (2019)

Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine
por: Preuß, Stefanie, et al.
Publicado: (2012)

The Impact of Glycosyl-Phosphatidyl-Inositol Anchored MICA Alleles on Novel NKG2D-Based Therapies
por: Valés-Gómez, Mar
Publicado: (2015)

Gedunin and Azadiradione: Human Pancreatic Alpha-Amylase Inhibiting Limonoids from Neem (Azadirachta indica) as Anti-Diabetic Agents
por: Ponnusamy, Sudha, et al.
Publicado: (2015)

Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients
por: Garcia, Cristiana C., et al.
Publicado: (2018)

Understanding the Mannose Transfer Mechanism of Mycobacterial Phosphatidyl-myo-inositol Mannosyltransferase A from Molecular Dynamics Simulations
por: Bhattacharje, Gourab, et al.
Publicado: (2022)

Determination of pH Effects on Phosphatidyl-Hydroxytyrosol and Phosphatidyl-Tyrosol Bilayer Behavior
por: Evans, Kervin O., et al.
Publicado: (2018)

Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension
por: Aarthy, Thiagarayaselvam, et al.
Publicado: (2018)

Glycogen Synthase Kinase-3
por: Crouch, Peter, et al.
Publicado: (2011)

Inositol phosphate kinases in the eukaryote landscape
por: Laha, Debabrata, et al.
Publicado: (2021)

Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
por: Elumalai, Perumal, et al.
Publicado: (2014)

Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis: STRUCTURAL AND MUTATIONAL ANALYSIS OF MANNOSYLTRANSFERASE CORYNEBACTERIUM GLUTAMICUM PimB′
por: Batt, Sarah M., et al.
Publicado: (2010)

Glycosyl-Phosphatidyl-Inositol (GPI)-Anchors and Metalloproteases: Their Roles in the Regulation of Exosome Composition and NKG2D-Mediated Immune Recognition
por: López-Cobo, Sheila, et al.
Publicado: (2016)

Utility of Prostate-Specific Antigen Isoforms and Prostate Health Index in the Diagnosis of Metastatic Prostate Cancer
por: Raju, Govinda Nanjaiah Laxmana, et al.
Publicado: (2022)

Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair
por: Jadav, Rathan S., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1rho6qhaha7b91u1nm7a2c6b18