Cargando…

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

Ras mediates cell proliferation, survival and differentiation. Mutations in K-Ras4B are predominant at residues G12, G13 and Q61. Even though all impair GAP-assisted GTP → GDP hydrolysis, the mutation frequencies of K-Ras4B in human cancers vary. Here we aim to figure out their mechanisms and differ...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Shaoyong, Jang, Hyunbum, Nussinov, Ruth, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763299/
https://www.ncbi.nlm.nih.gov/pubmed/26902995
http://dx.doi.org/10.1038/srep21949