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Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy

RATIONALE: The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of many entities. METHODS AND RESULTS: A 1 year retrospective study of pediatric pat...

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Autores principales: Poza-Guedes, Paloma, Barrios, Yvelise, González-Pérez, Ruperto, Sánchez-Machín, Inmaculada, Franco, Andres, Matheu, Víctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763406/
https://www.ncbi.nlm.nih.gov/pubmed/26909103
http://dx.doi.org/10.1186/s13223-016-0111-7
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author Poza-Guedes, Paloma
Barrios, Yvelise
González-Pérez, Ruperto
Sánchez-Machín, Inmaculada
Franco, Andres
Matheu, Víctor
author_facet Poza-Guedes, Paloma
Barrios, Yvelise
González-Pérez, Ruperto
Sánchez-Machín, Inmaculada
Franco, Andres
Matheu, Víctor
author_sort Poza-Guedes, Paloma
collection PubMed
description RATIONALE: The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of many entities. METHODS AND RESULTS: A 1 year retrospective study of pediatric patients complaining exclusively gastrointestinal symptoms after cow’s milk consumption and at least one positive specific IgE (sIgE) to cow’s milk (CM) proteins (CMP) was done (n = 39). The most prevalent symptom was abdominal cramps in 35 patients (90 %), discomfort or abdominal distention in 30 patients (75 %), diarrhea in 10 patients (25 %) and constipation in 5 patients (12 %). IgA anti-transglutaminase antibodies were absent and lactose intolerance was ruled out in all patients. Average of total IgE on this group was 288 UI/ml. sIgE against β-lactoglobulin was the dominant with an average of 4.14 kU/l. sIgE to casein (CAS), which is the dominant protein in systemic anaphylaxis was 1.74 kU/l; sIgE to α-lactoalbumin, the other whey protein, was 0.83 kU/l and sIgE levels to CM were 0.78 kU/l. The quotient sIgE CAS/sIgE β-lactoglobulin in these patients was always lower than 1. Patients experienced an improvement of their symptoms after a CM free diet. An open oral challenge with CM did mimic their initial symptoms in all patients. However, the open oral challenge with dairy products was well tolerated. CONCLUSIONS: Patients with a specific phenotype of GI allergy with CM have specific IgE against β-lactoglobulin, as a dominant sIgE. These patients could beneficiate of a diet with dairy products.
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spelling pubmed-47634062016-02-24 Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy Poza-Guedes, Paloma Barrios, Yvelise González-Pérez, Ruperto Sánchez-Machín, Inmaculada Franco, Andres Matheu, Víctor Allergy Asthma Clin Immunol Short Report RATIONALE: The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of many entities. METHODS AND RESULTS: A 1 year retrospective study of pediatric patients complaining exclusively gastrointestinal symptoms after cow’s milk consumption and at least one positive specific IgE (sIgE) to cow’s milk (CM) proteins (CMP) was done (n = 39). The most prevalent symptom was abdominal cramps in 35 patients (90 %), discomfort or abdominal distention in 30 patients (75 %), diarrhea in 10 patients (25 %) and constipation in 5 patients (12 %). IgA anti-transglutaminase antibodies were absent and lactose intolerance was ruled out in all patients. Average of total IgE on this group was 288 UI/ml. sIgE against β-lactoglobulin was the dominant with an average of 4.14 kU/l. sIgE to casein (CAS), which is the dominant protein in systemic anaphylaxis was 1.74 kU/l; sIgE to α-lactoalbumin, the other whey protein, was 0.83 kU/l and sIgE levels to CM were 0.78 kU/l. The quotient sIgE CAS/sIgE β-lactoglobulin in these patients was always lower than 1. Patients experienced an improvement of their symptoms after a CM free diet. An open oral challenge with CM did mimic their initial symptoms in all patients. However, the open oral challenge with dairy products was well tolerated. CONCLUSIONS: Patients with a specific phenotype of GI allergy with CM have specific IgE against β-lactoglobulin, as a dominant sIgE. These patients could beneficiate of a diet with dairy products. BioMed Central 2016-02-23 /pmc/articles/PMC4763406/ /pubmed/26909103 http://dx.doi.org/10.1186/s13223-016-0111-7 Text en © Poza-Guedes et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Poza-Guedes, Paloma
Barrios, Yvelise
González-Pérez, Ruperto
Sánchez-Machín, Inmaculada
Franco, Andres
Matheu, Víctor
Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
title Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
title_full Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
title_fullStr Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
title_full_unstemmed Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
title_short Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
title_sort role of specific ige to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763406/
https://www.ncbi.nlm.nih.gov/pubmed/26909103
http://dx.doi.org/10.1186/s13223-016-0111-7
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