Cargando…

Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis

BACKGROUND: Tumor necrosis factor (TNF) has pleiotropic functions during both the demyelinating autoimmune disease multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). How TNF regulates disability during progressive disease remains unresolved. Using a progres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valentin-Torres, Alice, Savarin, Carine, Hinton, David R., Phares, Timothy W., Bergmann, Cornelia C., Stohlman, Stephen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763407/ https://www.ncbi.nlm.nih.gov/pubmed/26906225 http://dx.doi.org/10.1186/s12974-016-0513-y

Ejemplares similares

Differential Regulation of Self-reactive CD4(+) T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2016)

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2015)

Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation
por: Valentin-Torres, Alice, et al.
Publicado: (2018)

MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2013)

Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system
por: de Aquino, Maria Teresa P., et al.
Publicado: (2013)

IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
por: Savarin, Carine, et al.
Publicado: (2012)

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability
por: Hindinger, Claudia, et al.
Publicado: (2012)

CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
por: Phares, Timothy W., et al.
Publicado: (2016)

Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
por: Phares, Timothy W, et al.
Publicado: (2012)

Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis
por: Hwang, Mihyun, et al.
Publicado: (2015)

Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2018)

MMP9 deficiency does not decrease blood–brain barrier disruption, but increases astrocyte MMP3 expression during viral encephalomyelitis
por: Savarin, Carine, et al.
Publicado: (2011)

IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis
por: Phares, Timothy W., et al.
Publicado: (2013)

PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
por: Kapil, Parul, et al.
Publicado: (2014)

Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery
por: Savarin, Carine, et al.
Publicado: (2015)

Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis
por: Cua, Daniel J., et al.
Publicado: (1999)

Interleukin‐10 is a critical regulator of white matter lesion containment following viral induced demyelination
por: Puntambekar, Shweta S., et al.
Publicado: (2015)

Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis
por: Parra, Beatriz, et al.
Publicado: (1997)

Dynamics of B cell subsets within the CNS during viral encephalomyelitis
por: Disano, Krista, et al.
Publicado: (2014)

Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination
por: Savarin, Carine, et al.
Publicado: (2018)

Splitting the “Unsplittable”: Dissecting Resident and Infiltrating Macrophages in Experimental Autoimmune Encephalomyelitis
por: Koeniger, Tobias, et al.
Publicado: (2017)

Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells
por: Zuo, Jun, et al.
Publicado: (2006)

Coronavirus infection of the central nervous system: host–virus stand-off
por: Bergmann, Cornelia C., et al.
Publicado: (2006)

Intrathecal Humoral Immunity to Encephalitic RNA Viruses
por: Phares, Timothy W., et al.
Publicado: (2013)

Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination
por: Savarin, Carine, et al.
Publicado: (2017)

Methylprednisolone inhibits IFN-γ and IL-17 expression and production by cells infiltrating central nervous system in experimental autoimmune encephalomyelitis
por: Miljković, Željka, et al.
Publicado: (2009)

Activated GL7(+) B cells are maintained within the inflamed CNS in the absence of follicle formation during viral encephalomyelitis
por: DiSano, Krista D., et al.
Publicado: (2017)

Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis
por: Lee, Sangmin, et al.
Publicado: (2019)

Clozapine reduces infiltration into the CNS by targeting migration in experimental autoimmune encephalomyelitis
por: Robichon, Katharina, et al.
Publicado: (2020)

Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis
por: Weier, Alicia, et al.
Publicado: (2022)

Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis
por: Bravo, Beatriz, et al.
Publicado: (2016)

Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation
por: Cardona, Astrid E, et al.
Publicado: (2008)

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis
por: Aarts, Suzanne ABM, et al.
Publicado: (2019)

Targeting central nervous system extracellular vesicles enhanced triiodothyronine remyelination effect on experimental autoimmune encephalomyelitis
por: Xiao, Yun, et al.
Publicado: (2021)

Neutralization of Interleukin-9 Decreasing Mast Cells Infiltration in Experimental Autoimmune Encephalomyelitis
por: Yin, Jun-Jie, et al.
Publicado: (2017)

Neurons promote encephalitogenic CD4(+) lymphocyte infiltration in experimental autoimmune encephalomyelitis
por: Nakazato, Yuki, et al.
Publicado: (2020)

The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System
por: Becher, Burkhard, et al.
Publicado: (2001)

CD24 Controls Expansion and Persistence of Autoreactive T Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis
por: Bai, Xue-Feng, et al.
Publicado: (2004)

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis
por: Sarma, Jayasri Das, et al.
Publicado: (2009)

Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents
por: Kesidou, Evangelia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hq6e3s98qps9rlooi731stvc9l