Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

BACKGROUND: PM100117 and PM100118 are glycosylated polyketides with remarkable antitumor activity, which derive from the marine symbiotic actinobacteria Streptomyces caniferus GUA-06-05-006A. Structurally, PM100117 and PM100118 are composed of a macrocyclic lactone, three deoxysugar units and a naph...

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Detalles Bibliográficos
Autores principales: Salcedo, Raúl García, Olano, Carlos, Gómez, Cristina, Fernández, Rogelio, Braña, Alfredo F., Méndez, Carmen, de la Calle, Fernando, Salas, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763440/
https://www.ncbi.nlm.nih.gov/pubmed/26905289
http://dx.doi.org/10.1186/s12934-016-0443-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763440/
https://www.ncbi.nlm.nih.gov/pubmed/26905289
http://dx.doi.org/10.1186/s12934-016-0443-5

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